Modeling of waste management systems is related to the simulation of the actual unit processes that make up the functioning logistics systems sorting, col-lection, transportation and disposal of waste. The paper presents the model of medical waste management system in the dynamic version which allows to design the most economically effective systems of medical wastes disposal and utilization.This paper describes the optimization study aimed to analyze the impact of the parameter describing the degree of reduction of medical waste in the process of combustion (wwp) and changes in the unitary cost of transportation of medical waste (Kij) on the value of the indicator of economic efficiency (E). The study was conducted on the example of the analysis of medical waste management system in Podlaskie Region.The range of operating tests created in the optimization study, was divided into two stages of optimization calculations for the adoption with the assumed technical and economic parameters. The first one generated the lowest operating cost of the scheme, while in the second stage the impact of the input parameters of the system was determined, i.e. the influence of reduction of amount of medical waste in the incineration process, and the unitary cost of ...